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Opioid action is due to the two very low affinity binding of the parent compound and better affinity binding of the O-demethylated metabolite M1 to µ-opioid receptors. In animal styles, M1 is as much as 6 periods more strong than tramadol in generating analgesia and two hundred occasions far more potent in µ-opioid binding.Ovaj lek treba uzimati